It is well known that there is marked increase of malignacy incidence after allograft transplantion, upto 100 times higher than general population.
At the end of 1991, there were about 2,400 functioning renal transplant recipients in Korea, who were received immunosuppressive medication and prone to develop malignancy.
We had diagnosed 10 cases (1.2%) of malignancies among the 820 renal transplant recipients from 1969 to 1992 in catholic Medical center Seven men and three women recipients were diagnosed as four stomach carcinoma, two malignant lymphoma, one
cervix
carcinoma, one adult type Wilm's tumor, one large cell lung carcinoma, one cervix carcinoma and one skin carcinoma. The duration from transplantation to diagnosis were 6 to 169 months (median 52 months0. 3 cases were managed with Aza and PDN, 5
cases
with CsA and PDN and 1 case with triple regimens. The therapeutic results were five alive with functioning graft and five death (one death caused by uremia and four deaths associated with malignancy).
As increase of kidney transplantation and prolongation of the survival. The overall number of immunosuppressed allograft recipents increases rapidly. Early detection and proper therapeutic strategy of malignancies for these patients must be well
estabilished.
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